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10.1016/j.celrep.2023.113148 Cell Rep

In conclusion, it is still controversial what determines whether CG methylation stays static (irreversible) or dynamic (reversible) during the life

Berberine (BBR) is an isoquinoline alkaloid that occurs naturally and has been proposed as a potential neuroprotectant, since it has been found to exert multiple effects to modulate most of the pathological hallmarks of NDs, including neuroinflammation, oxidative stress, mitochondrial dysfunction, and protein aggregation